I-immune hyperactivity

Ukuphefumula kanzima kwenzeka ezigulini ezinesifuba somoya ngenxa ye-bronchitis. Empeleni, iyisimiso sokuzivikela komzimba esisebenza ngokweqile ekuphenduleni izinto ezingezwani nomzimba ezifana nothuli, intuthu, ukungcola noma ezinye izisusa.

Kuyaphawuleka ukuthi ucwaningo lwangaphambilini lwalugxile ephrotheni ebizwa ngokuthi i-JAK1, edlala indima ebalulekile ekuvuseleleni ukusabela komzimba ngokuthumela izimpawu kumangqamuzana omzimba omzimba abizwa ngokuthi ama-phagocyte aqeda imizimba yangaphandle.

Kodwa naphezu kokubaluleka kwayo, i-JAK1 ngezinye izikhathi ingaba namandla ngokweqile futhi ivuse ama-macrophages, okuholela ekuvuvukeni, okungabonakala ezinhlobonhlobo zezimo, njenge-Crohn's disease, isifo samathambo kanye nesifo sesifuba somoya. Ama-Janus kinase inhibitors, noma i-JAK ngamafuphi, avele njengokwelashwa okungaba khona kulezi zimo.

i-molecule "itaconate"

Ocwaningweni olusha, abacwaningi base-Trinity University bahlonze inhibitor ye-JAK, ekhiqizwa umzimba womuntu. I-molecule, eyaziwa ngokuthi i-itaconate, yatholwa isebenza njengohlobo lokuvala ukuvuvukala ngokubeka amabhuleki kuma-macrophage asebenza ngokweqile.

Kuphinde kuvele ukuthi kusebenze ku-JAK1, futhi lamaphethini ahlanganisiwe abonakala evala ukuvuvukala okusiza ukulwa nesifo somoya.

amathemba aphezulu

Abacwaningi baphinde bahlola okuphuma ku-itaconate okubizwa ngokuthi i-4-OI kumamodeli egundane esifuba somoya esinamandla, esingaphenduli ekwelashweni okujwayelekile kwe-anti-inflammatory steroid. I-molecule itholwe ukuthi yehlisa ukusebenza kwe-JAK1 inhibitor futhi inciphise ukuqina kwesifuba somoya kumagundane.

UDkt Marh Runch, umcwaningi oholayo walolu cwaningo, uthe: "Kunamathemba amakhulu okuthi izidakamizwa ezintsha ezisekelwe ku-itaconate zingaba namandla njengendlela entsha yokwelapha yokwelapha isifuba somoya esibi kakhulu, lapho kunesidingo esiphuthumayo sezindlela zokwelapha ezintsha."