Amanye amabhaktheriya amathumbu abangela ukukhuluphala

Amanye amabhaktheriya amathumbu abangela ukukhuluphala

Ucwaningo lwakamuva olwenziwe ithimba labacwaningi bamazwe ngamazwe lubonise ukuthi izinto ezinobuthi ezivuza emathunjini zingaphazamisa ukusebenza kwamangqamuzana amafutha futhi ziholele ekukhuluphaleni, ngokusho kwalokho okubikwe kuwebhusayithi ye-"Science Alert".

Imiphumela yalolu cwaningo, eshicilelwe kumagazini i-BMC Medicine, ivula umnyango wokuthi ungabhekana kanjani nokukhuluphala ngokweqile nokuyingozi esikhathini esizayo.

Izinto, ezibizwa ngokuthi ama-endotoxins, ziyizingxenyana zamagciwane emathunjini ethu. Naphezu kokuba yingxenye yemvelo yesistimu yokugaya ukudla, udoti we-microbial ungabangela umonakalo omkhulu emzimbeni uma uthola indlela yawo egazini.

Abacwaningi bafuna ukubheka ngokuqondile umphumela we-endotoxins kumaseli amafutha (adipocytes) kubantu. Bathole ukuthi izinqubo ezibalulekile ezivame ukusiza ukulawula ukunqwabelana kwamafutha zithintwa yizinto.

Lolu cwaningo lwenziwe kwabangu-156 ababambiqhaza, abangu-63 kubo okuthiwe abakhuluphele, abangu-26 kubo bahlinzwa i-bariatric - ukuhlinzwa lapho kuncipha ubukhulu besisu ukuze kwehliswe ukudla.

Amasampula avela kulaba ababambiqhaza acutshungulwe elebhu lapho ithimba libheke izinhlobo ezimbili ezihlukene zamaseli amafutha, achazwa njengamhlophe nansundu.

"Izicucu ze-gut microbiota ezingena egazini zinciphisa ukusebenza okujwayelekile kwamangqamuzana amafutha kanye nokusebenza kwe-metabolic, okuba kubi kakhulu ngokukhula kwesisindo, okunomthelela ekwendeni kwengozi yokuba nesifo sikashukela," kusho isazi sebhayoloji yamangqamuzana uMark Christian waseNottingaan Trent University e-UK. Kubonakala sengathi njengoba sikhuluphala, izitolo zethu zamafutha azikwazi ukukhawulela umonakalo okungenzeka izingxenye ze-gut microbiome yethu emangqamuzaneni amafutha. "

Futhi amangqamuzana amafutha amhlophe, akha ingxenye enkulu yezicubu zethu zokugcina amafutha, agcina amafutha ngamanani amakhulu. Amaseli amafutha ansundu athatha amafutha agciniwe futhi awaphule esebenzisa i-mitochondria yawo eminingi, njengalapho umzimba ubanda futhi udinga ukufudumala. Ngaphansi kwezimo ezifanele, umzimba ungaguqula amangqamuzana amhlophe agcina amafutha aziphatha njengamaseli amafutha ansundu ashisa amafutha.

Ukuhlaziywa kwabonisa ukuthi ama-endotoxins anciphisa amandla omzimba okuguqula amangqamuzana amafutha amhlophe abe amangqamuzana afana namafutha futhi anciphise inani lamafutha agcinwe.

Le nqubo ibhekwa njengebalulekile ekugcineni isisindo esinempilo, futhi uma ososayensi bengafunda kabanzi mayelana nendlela esebenza ngayo nokuthi bangasilawula kanjani, ivula izindlela zokwelapha ezingase zibe khona zokukhuluphala.

Ababhali bocwaningo baphinde baveze ukuthi ukuhlinzwa kwe-bariatric kunciphisa amazinga e-endotoxins egazini, okwandisa inani layo njengendlela yokulawula isisindo. Kufanele kusho ukuthi ama-fat cells akwazi ukusebenza ngokujwayelekile.

“Ucwaningo lwethu luqokomisa ukubaluleka kwamathumbu namafutha njengezitho ezibalulekile ezincikene ezithonya impilo yethu ye-metabolic,” kusho uChristian. Ngakho-ke, lo msebenzi uphakamisa ukuthi isidingo sokunciphisa ukulimala kwamangqamuzana e-endotoxin okubangelwa i-endotoxin sibaluleke nakakhulu uma ukhuluphele, njengoba i-endotoxin inomthelela ekwehleni kwe-metabolism yamaselula enempilo. "

Zonke izinhlobo zezinto zidlala indima endleleni esilawula ngayo isisindo sethu ezingeni lebhayoloji, futhi manje kunesinye isici esibalulekile okufanele sicatshangelwe. Njengoba ukukhuluphala kanye nezinkinga zempilo ezihambisana nazo kuba inkinga yomhlaba wonke, sidinga konke ukuqonda esingakuthola.

Izibikezelo ze-horoscope zika-Maguy Farah zonyaka ka-2023