Ucwaningo olusha oluthembisayo lweziguli ezinokuhluleka kwenhliziyo

Ucwaningo olusha oluthembisayo lweziguli ezinokuhluleka kwenhliziyo

Ukwehluleka kwenhliziyo kuyinkinga yezempilo yomhlaba wonke evame ukwenziwa inkimbinkimbi ukuphelelwa umoya lapho umuntu elele, ukugula okuhambisana nakho okwenza kube mfushane kakhulu isikhathi sokuphila komuntu.

Ezindabeni ezinhle, nokho, isidakamizwa esisha esithembisayo senziwe ososayensi abavela eNyuvesi yase-Auckland eNew Zealand esingakwazi ukwelapha ukuhluleka kwenhliziyo kanye nenkinga yokulala ngokuqondisa umsebenzi wezinzwa okushayela kokubili, ngokusho kwe-Nature Communications.

Kubantu abanesifo senhliziyo ukubikezela kubi futhi izinga lokufa liphezulu naphezu kwentuthuko yakamuva yokwelashwa.

Ngokusho kwe-US National Institutes of Health (NIH), ukwehluleka kwenhliziyo kuthinta abantu abangaphezu kwezigidi ezingu-64 emhlabeni jikelele, okwenza kube yinto ehamba phambili yezempilo yomphakathi emhlabeni jikelele.

Iziguli ezingaphezu kwezigidi ezingu-64

Kubantu abanesifo senhliziyo, ukubikezelwa kubi futhi izinga lokufa liphezulu naphezu kwentuthuko yakamuva yokwelashwa.

Ngokusho kwe-US National Institutes of Health (NIH), ukwehluleka kwenhliziyo kuthinta abantu abangaphezu kwezigidi ezingu-64 emhlabeni jikelele, okwenza kube yinto ehamba phambili yezempilo yomphakathi emhlabeni jikelele.

ukufa kusenesikhathi

Ukwehluleka kwenhliziyo kwenzeka lapho umsipha wenhliziyo uba buthaka futhi ungampompi ngempumelelo. Ubuchopho busabela ekuhlulekeni kwenhliziyo ngokwenza kusebenze isimiso sezinzwa esizwelayo somzimba, impendulo "yokulwa noma yokundiza", ukuze kushukumise inhliziyo ukuthi iphampe ngempumelelo.

Kodwa ukugqugquzelwa kwesikhathi eside, okuhlangene ne-obstructive sleep apnea, kuholela ekunciphiseni ubude besikhathi sokuphila. Iziguli eziningi zifa kungakapheli iminyaka emi-5 kutholwe ukuthi zinesifo senhliziyo.

ama-chemoreceptors

Kuyaziwa ukuthi ingxenye yobuchopho ethumela umfutho enhliziyweni iphinde ilawule ukuphefumula, nokuthi i-central sleep apnea (CSA) yenzeka lapho ukuphefumula kuma ngokuphindaphindiwe phakathi nokulala ngenxa yokuthi ubuchopho abuyithumeli izimpawu ezifanele emisipha yokuphefumula, isimo. evamile kubantu abanesifo senhliziyo.

Kukholakala ukuthi i-apnea yokulala ibangelwa ukwanda kokuzwela kuma-chemoreceptors aseduze atholakala emithanjeni ye-carotid, ebona ngokuqondile izinguquko ku-arterial blood oxygenation, noma i-hypoxia, futhi iqale ukusabela ukuze kubuyiselwe amazinga komoyampilo evamile. I-receptor eyodwa, i-P2X3, ithonya le mpendulo ye-reflex.

Isidakamizwa se-AF-130

Ukwelashwa kwamanje kwe-apnea yokulala kuwukucindezela okuqhubekayo kwe-airway (CPAP), esebenzisa ukucindezela komoya okuthambile ukugcina imigudu yomoya ivulekile.

Kodwa-ke, umfutho womoya oqhubekayo, odinga ukugqoka imaskhi ebambayo ngenkathi ulele, awusimame.

Ukwelashwa okuthembisayo maduze

Okusha ukuthi kuye kwasungulwa umuthi omusha othembisayo oqondise ukusebenza kwemizwa okubangela ukuhluleka kwenhliziyo kanye nenkinga yokulala.

Abacwaningi baseNyuvesi yase-Auckland bahlole umuthi, owaziwa nge-AF-130, kumagundane anokwehluleka kwenhliziyo okungapheli kanye ne-apnea. I-AF-130 yaboniswa iyisitha esinamandla se-P2X3, esenza kujwayeleke ukusabela kwesistimu yokuphefumula ku-hypoxia futhi ithuthukise kakhulu inani legazi elimpontshwa yinhliziyo. Izinkinga zokuphefumula zaqedwa.

Umuthi omusha uhlelelwe ukuthi ugunyazwe maduze yi-US Food and Drug Administration (FDA), nakuba uzosetshenziswa emtholampilo ohlukile, okusho ukuthi ukuhlolwa kwabantu kungase kwenzeke eminyakeni emibili ezayo.

Izibikezelo ze-horoscope zika-Maguy Farah zonyaka ka-2023