Ukwelapha izifo ezinzima nge-corona nge...?

Isivivinyo somtholampilo, okushicilelwe yimiphumela, ngoLwesithathu, ephephabhukwini lezokwelapha eliyisipesheli, sakhombisa ukuthi umuthi “tofacitinib” wokwelapha isifo samathambo ukhombise imiphumela ethembisayo ekwelapheni iziguli ezinezimpawu ezinzima ze-Covid-19.

Futhi ukuqulwa kwecala lomtholampilo, imiphumela yalo eyashicilelwa ku- “New England Journal of Medicine,” kwenzeka kubantu abangama-289 ababelashwa ezibhedlela ezindaweni eziyi-15 ezihlukene eBrazil ngenxa yezimpawu ezinzima ze-Covid-19.

Ingxenye yalezi ziguli yanikezwa i-tofacitinib (amaphilisi amabili angu-10 mg ngosuku) ngokuhlangene nokunakekelwa kwezempilo okuvamile kanti enye ingxenye yanikezwa i-placebo enokunakekelwa kwezempilo okufanayo.

Ngemva kwezinsuku ezingu-28, u-18% weqembu elathola umuthi lalingase libe nokwehluleka ukuphefumula (isb., lidinga ukuthululwa noma ukufinyelela endaweni yokuphefumula) noma selishonile, uma kuqhathaniswa nama-29% eqembu le-placebo.

Sekukonke, u-5.5% weziguli ze-placebo zafa, uma kuqhathaniswa no-2.8% eqenjini le-tofacitinib.

I-Tofacitinib imakethwa ngaphansi kwemikhiqizo ehlukahlukene, okuhlanganisa iZeljans, ephethwe yiqembu lezemithi laseMelika iPfizer.

"Sikhuthazwe imiphumela yokuqala yokuhlolwa kwethu okungahleliwe kwe-tofacitinib ezigulini ezilaliswe esibhedlela ezinenyumoniya edalwe yi-Covid-19," kusho u-Otavio Berwanger, udokotela esibhedlela i-Albert Einstein Hospital kwa-Israel obeqhuba lolu cwaningo ngokubambisana noPfizer.

I-Tofacitinib igunyazelwe ukusetshenziswa e-United States ukwelapha isifo samathambo, i-psoriatic arthritis, ne-ulcerative colitis.

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