Ukuthola ubudlelwano obuseduze phakathi kwamathumbu nobuchopho

Ukuthola ubudlelwano obuseduze phakathi kwamathumbu nobuchopho

Ubufakazi obukhulayo buphakamisa ukuthi amashumi ezigidigidi zama-microbes avame ukuhlala emathunjini - okuthiwa yi-gut microbiome - anemiphumela efinyelela kude endleleni umzimba womuntu osebenza ngayo. Umphakathi we-microbial ukhiqiza amavithamini, usiza ukugaya ukudla, uvimbela ukukhula kwamagciwane ayingozi, futhi ulawula amasosha omzimba, phakathi kwezinye izinzuzo.

Ukwelashwa kwe-neurodegeneration

Ngokwalokho okushicilelwe yi-"Neuroscience News" ecaphuna iphephabhuku elithi "Science", ucwaningo olusha olwenziwe abacwaningi baseWashington University School of Medicine e-St. Louis kumagundane aselabhorethri lubonisa ukuthi i-gut microbiome idlala indima enkulu empilweni. yobuchopho bomuntu.

Ucwaningo luthole ukuthi amagciwane amathumbu - ngokwengxenye ngokukhiqiza izinhlanganisela ezifana ne-short-chain fatty acids - anomthelela ekuziphatheni kwamangqamuzana omzimba kuwo wonke umzimba, kuhlanganise nalawo asebuchosheni angalimaza izicubu zobuchopho futhi abhebhethekise ukuwohloka kwemizwa ezimweni ezifana nesifo i-Alzheimer's. .

Okutholwe okusha kuvula iminyango yokuthi kungenzeka kushintshwe i-gut microbiome njengendlela yokuvimbela noma yokwelapha i-neurodegeneration.

Isiphetho esimangalisayo

"Sinikeze ama-antibiotic amancane amagundane isonto elilodwa nje kuphela, futhi sabona ushintsho oluhlala njalo kumagciwane abo amathumbu, izimpendulo zabo zokuzivikela komzimba, kanye nenani le-neurodegeneration elihlobene neprotheni ebizwa ngokuthi i-tau ababhekana nayo lapho bekhula," kusho umlobi ophezulu wocwaningo. UProfesa Ohlonishwayo Wesayensi Yezinzwa, uProfesa David Holtzman.Okutholakele okumangazayo ukuthi "ukuphatha i-gut microbiome kungaba indlela yokuthonya ubuchopho ngaphandle kokufaka noma yini ngqo ebuchosheni."

Ubufakazi buyanda bokuthi ama-gut microbiomes abantu abanesifo i-Alzheimer's angahluka kwawabantu abanempilo. Kepha akucaci ukuthi lo mehluko uyimbangela noma umphumela walesi sifo - noma zombili - nokuthi imuphi umphumela i-microbiome eguquliwe engaba nawo ekuhambeni kwalesi sifo.

Ukuguqulwa kofuzo

Ukunquma ukuthi i-gut microbiome idlala indima eyimbangela, abacwaningi baguqule ama-gut microbiomes amagundane athambekele ekulimaleni kobuchopho njengesifo i-Alzheimer's kanye nokukhubazeka kwengqondo.

Amagundane akhelwe ukuveza uhlobo oluguquliwe lweprotheyini ye-tau yobuchopho bomuntu, enqwabelana futhi ibangele ukulimala kwe-neuronal kanye ne-atrophy ebuchosheni bawo lapho eneminyaka eyizinyanga eziyi-9.

Baphinde balayisha okuhlukile kofuzo lomuntu lwe-APOE, into enkulu yofuzo engcupheni yesifo i-Alzheimer's. Abantu abanekhophi eyodwa yokwehluka kwe-APOE4 banamathuba aphindwe kathathu noma kane okuthuthukisa isifo kunabantu abanokwehluka okuvamile kwe-APOE3.

Indlela entsha yokuvimbela

"Lolu cwaningo lungase lunikeze ukuqonda okubalulekile kokuthi i-microbiome ithinta kanjani i-tau-mediated neurodegeneration," kusho uSolwazi Linda McGovern, umqondisi we-US National Institute of Neurological Disorders.

Okutholakele kusikisela indlela entsha yokuvimbela nokwelapha izifo ze-neurodeergenerative ngokushintsha i-gut microbiome ngama-antibiotics, ama-probiotics, ukudla okukhethekile, noma ezinye izindlela.

Iqala eminyakeni yobudala ephakathi

Ngakolunye uhlangothi, uProf Holtzmann uthe okutholakele kusikisela ukuthi "ukwelashwa kungaqalwa kubantu abaneminyaka ephakathi ngesikhathi besajwayelekile ngokwengqondo kodwa besonqenqemeni lokukhubazeka", echaza ukuthi uma ukwelashwa kungaqala ngezinhlobo zezilwane ezizwelayo ngokofuzo zabantu abadala Ngokuwohloka kwemithambo yegazi. ngaphambi kokuba lesi sifo sibonakale okokuqala, futhi ukwelashwa kuboniswa ukuthi kusebenza, lokhu kungase kube iphuzu lapho izivivinyo zemitholampilo yabantu zingaqala khona.

Izimbangela ezinamandla ezikhuthazayo zezifo zemizwa kanye ne-Alzheimer's