Biological wachi

Circadian rhythm ndeye yakasikwa yemukati maitiro anotevera 24-awa kutenderera inodzora kurara, kugaya, kudya, uye kunyangwe kusadzivirirwa.

Zvinhu zvakaita sechiedza chekunze, kudya chikafu chenguva dzose, uye kurovedza muviri pamwe chete zvinobatsira kuchengeta wachi yebhayoloji ichishanda mukuwirirana. Sezvineiwo, kuita zvinhu zvidiki sekunonoka kunonoka pane zvakajairika, kana kunyange kudya pane imwe nguva yakasiyana nemazuva ese, zvinogona kukanganisa "wachi" yako yemukati.

Utano hwepfungwa nekenza

Masayendisiti anobva kuNew York State University's Institute of Applied Sayenzi anopa zano rekuti iwe unofanirwa kuchengetedza mutinhimira wako wecircadian uchishanda nemazvo, sezvo kukanganisa kwekutenderera uku kwakabatanidzwa kune akati wandei matambudziko ehutano, anosanganisira kusagadzikana kwehutano hwepfungwa, kenza uye chirwere cheAlzheimer.

Tsvagiridzo inoratidza kuti kune varwere vane chirwere cheAlzheimer, kuvhiringika kwecircadian rhythm kunowanzoonekwa sekuchinja kwemaitiro ekurara kwemurwere anoitika nguva refu chirwere chisati chanyatsobuda pachena. Mamiriro acho anowedzera mumatanho ekupedzisira echirwere. Asi hazvisati zvanyatsonzwisiswa kana kushaya hope kunokonzera chirwere cheAlzheimer, kana kuti chinoitika nekuda kwechirwere.

brain plaques

Vatsvaguri vari kugara vachiwana chinhu chakafanana muhuropi hwevanhu vane chirwere cheAlzheimer's kuunganidzwa kwemapuroteni anonzi "beta-amyloid", ayo anowanzo kuungana muuropi uye kuumba "plaques" muuropi. Beta-amyloid plaques inokanganisa kushanda kwemasero europi, izvo zvinogona kutungamirira kumatambudziko ekuziva, zvakadai sekurasikirwa kwendangariro. Muhuropi hwakajairika, puroteni inocheneswa nguva nenguva isati yawana mukana wekukonzera matambudziko.

biological rhythm kutenderera wachi

Mhedzisiro yeongororo yazvino yakaratidza kuti masero ane basa rekubvisa beta-amyloid plaques uye kuchengetedza uropi hune hutano zvakare anotevera 24-awa circadian rhythm, zvinoreva kuti kana iyo circadian rhythm ikavhiringidzwa, zvinogona kuita kuti zvinyanye kuoma kubvisa masero anokuvadza eplaque ane chekuita nechirwere cheAlzheimer. .

macrophages

Kuti vaite tsvakiridzo yavo, timu yevaongorori yakanyatso ongorora macrophages, ayo anonziwo macrophages uye ayo anowanzo kutenderera mune akawanda anobatanidza tishu mumuviri, kusanganisira uropi. Macrophages inonyanya kudya mabhakitiriya kana kunyange mapuroteni asina kuumbwa zvakanaka, izvo zvinogona kuonekwa sengozi kumuviri.

Kuti unzwisise kana maseru edziviriro aya anotevera rhythm ye circadian, vaongorori vakashandisa macrophages akatorwa kubva kumakonzo uye akagadzirwa murabhoritari. Uye pavakadyisa masero ne beta-amyloid, vakaona kuti kukwanisa kwema macrophages kubvisa beta-amyloid kwakachinja pamusoro peawa makumi maviri nemana.

Mapuroteni "proteoglycans"

Izvo zvakaratidzwawo kuti mamwe mapuroteni ari pamusoro pemacrophages, anonzi proteoglycans, ane yakafanana circadian rhythm zuva rese. Zvakazoitika kuti apo huwandu hweproteoglycans hwakanga hwakaderera, kukwanisa kubvisa mapuroteni e-beta-amyloid kwaive kwepamusoro-soro, zvinoreva kuti apo macrophages aiva neproteoglycans yakawanda, haana kubvisa beta-amyloid. Vatsvagiri vakawanawo kuti macrophage payakarasikirwa neyakajairwa circadian rhythm, vakamira kuita basa rekurasa beta-amyloid protein semazuva ese.

Masero ekudzivirira europi

Kunyangwe ichangoburwa ongororo yakashandisa macrophages kubva mumuviri wemakonzo kazhinji uye kwete kubva muuropi zvakananga, mhedzisiro kubva kune dzimwe ongororo dzakaratidza kuti microglia - brain immune masero (ayo ariwo imwe mhando ye macrophage muuropi) - ane Zvakare zuva nezuva biological. rhythm. Iyo circadian wachi inogadzirisa zvese zvine chekuita nebasa uye kuumbwa kwe microglia pamwe nemhinduro yavo yekudzivirira. Zvinogoneka kuti microglial circadian rhythms zvakare ine basa rekudzora neural kutaurirana - izvo zvinogona kupedzisira zvakonzera kuwedzera kwezviratidzo zvine chekuita nechirwere cheAlzheimer, kana kunyange matambudziko ekurara anogona kuwanikwa nevanhu vakuru.

Zvimwe zvinopokana

Asi mune zvidzidzo zvakatarisa zvipenyu zvose (zvakadai sembeva) pane kungoita masero, zvakawanikwa pahukama pakati pechirwere cheAlzheimer uye circadian rhythms zvave zvichinyanya kupesana, sezvo ivo vanowanzokundikana kubata matambudziko ose anowanikwa muvanhu vane chirwere cheAlzheimer, sezvazviri Ndizvo chete kana uchidzidza mamwe masisitimu kana mapuroteni anogona kukanganiswa nechirwere cheAlzheimer kuti anogona kusapa mufananidzo wakanyatso kumiririra wekuti chirwere cheAlzheimer chinoitika sei muvanhu.

Kuwedzera kwechirwere cheAlzheimer

Muzvidzidzo zvevanhu vane chirwere cheAlzheimer, vatsvakurudzi vakawana kuti kutadza kwe circadian rhythms kunogona kukuvadza mamiriro acho apo chirwere chinokura. Zvimwe zvakawanikwa patsvagurudzo zvakaratidzawo kuti kuvhiringwa kwecircadian rhythm kwakabatana nezvinetso zvekurara uye chirwere cheAlzheimer, pamwe nehuropi kusakwanisa kuchenesa uropi (kusanganisira beta-amyloid), zvichikonzera zvakanyanya kumatambudziko ekurangarira. Asi zvakaoma kuziva kana kukanganisa kwe circadian rhythm (uye matambudziko ainokonzera) angave akaitika nekuda kwechirwere cheAlzheimer, kana kuti chaiva chikamu chechikonzero chechirwere.

Kurara kwemhando yepamusoro kunofanirwa

Kana ikadzokororwa muvanhu, zvakawanikwa muchidzidzo ichi zvingangopa nhanho padyo nekunzwisisa imwe yenzira idzo rhythm dze circadian dzakabatana nechirwere cheAlzheimer. Pakupedzisira, zvinobvumiranwa zvakanyanya kuti kurara kwakakosha kune zvakawanda zvehutano hwevanhu, saka kuchengetedza rhythm ye circadian kwakakosha uye kwakakosha kuchengetedza mamiriro akanaka epfungwa, psyche, manzwiro uye hutano hwese.