Ngabe ama-nanobodies angaba yisixazululo seCorona?

Esivivinyweni sokuqala sama-nanobodies afana namasosha omzimba e-monoclonal, kodwa mancane, azinzile futhi ashibhile ukuwakhiqiza, abacwaningi base-American University of Pittsburgh School of Medicine babonise ukuthi ama-nanobodies angahogeleki aqondise iphrotheni “ye-spike” ye-coronavirus esafufusa, ingaba Ukuvimbela nokwelapha izifo ezinzima.

Emininingwaneni yocwaningo olwanyatheliswa encwadini ethi "Science Advances", futhi olwenziwa kuma-hamster, abacwaningi babonise ukuthi imithamo ephansi ye-aerobic nanobody ebizwa ngokuthi i-Nanobody - 21 "PiN - 21", engadonswa ivikela ama-hamster esisindweni esimangalisayo. ukulahlekelwa ngokuvamile okuhlotshaniswa nokutheleleka ngegciwane okunzima.Futhi kunciphisa inani lezinhlayiya zegciwane elithathelwanayo emigodini yamakhala, umphimbo namaphaphu izikhathi eziyisigidi, uma kuqhathaniswa nokwelashwa kwe-placebo esebenzisa i-nanobody engawenzi umthelela wegciwane.

Uchaze ukuthi ngokusebenzisa i-inhalation therapy enganikezwa ngqo endaweni yokutheleleka emgudwini wokuphefumula nasemaphashini, singenza ukwelashwa kuphumelele, eveza ukuthi ithemba likhulu, ikakhulukazi ngemuva kokuthi i-nanobody (PiN - 21) iqinisekisile ukuthi. ingavikela kakhulu ezifweni ezinzima, futhi ingaba Ivimbela ukudluliswa kwegciwane lisuka komunye umuntu liye komunye.

Umuthi wokugoma uyisixazululo esingcono kakhulu

Ososayensi kwadingeka banqobe izinselele eziningi zobuchwepheshe kulolu cwaningo, njengoba ama-nanoparticles kufanele afinyelele ekujuleni kwephaphu, futhi izinhlayiya zokwelashwa kufanele zibe zincane ngokwanele ukuze zingahlangani futhi zibe namandla ngokwanele ukuze zimelane nokucindezela okukhulu.

Ama-PiN-21 nanobodies, amancane izikhathi ezi-4 kunamasosha omzimba avamile anokuqina okuphakeme, awufanelekele lo msebenzi, ashibhile kakhulu ukukhiqiza, futhi angakhiqizwa ngokushesha ukuze avumelane ngokushesha negciwane elishintshashintsha isimo.

Ngaphezu kwalokho, abacwaningi baveze ukuthi ama-nanobodies kanye nemigomo iyahambisana futhi ayiqhudelani, futhi imigomo ihlala iyindlela engcono kakhulu yokuvimbela ukusabalala kwegciwane lisuka komunye liye komunye.

Wachaza ukuthi ama-nanobodies azosiza kuphela ekwelapheni abantu asebevele begula futhi abangakwazi ukugonywa ngezinye izizathu zezempilo.

Ezinye izihloko:

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